pharmaceutically acceptable salts and solvates thereof wherein X is halo, OC O R9, nitrate or sulfate; R1 and R2 are amino groups or together with the platinum atom to which they are attached, R1 and R2 form the ring NH2 CH2 v NH2 wherein v is 1, 2, 3, or 4 or R1 and R2 together can be any of the following groups a h; wherein A is H, CH3, OCH3, CF3 or NO2; R3 is N R26; wherein R26 is hydrogen or C1 C6alkyl; R4 is hydrogen, C1 6 alkyl, or CH2 R12; R6 is independently an amino, a nitro, NHC O R10, NHC O O R10, C O NHR10, OC O NHR10, or halo; R10 is hydrogen, C1 6 alkyl, phenyl, naphthyl, C3 6 cycloalkyl, norbornyl, or adamantyl; q is 0, 1, or 2; R5 is a direct bond, NH or C1 C6alkylene; or R5 and X together with the atoms to which they are attached form a 6 or 7 membered ring, wherein said 6 or 7 membered ring contains a linking group C O O or OC O; R7 is hydrogen, methyl, CH R17 R18, C O O R18, or OC O R18; wherein R17 is hydrogen or C1 6 alkyl; R18 is hydrogen, C1 6 alkyl, CH R19 R20, phenyl, naphthyl, C3 6 cycloalkyl, norbornyl, adamantyl, a natural or unnatural amino acid or a peptide; R19 is hydrogen or C1 6 alkyl; R20 is hydrogen, C1 6 alkyl; R8 is H or C1 6 alkyl; R9 is hydrogen, C1 6 alkyl, phenyl, naphthyl, C3 6 cycloalkyl, norbornyl, adamantyl, a natural or unnatural amino acid or a peptide; R11 and R12 are hydrogen, C1 6 alkyl, or either or both of R11 and R12 contain a reactive group on to which a linker and or one or more of compound W can be added; E is C1 C6alkylene; G is N or CR16; R16 is hydrogen or methyl; compound W is one or more amino acids, one or more sugars, polymeric ethers, C1 6alkylene phenyl NH C O R15, folic acid, О±vОІ3 integrin RGD binding peptide, tamoxifen, endoxifen, EGFR epidermal growth factor receptor antibody conjugates, kinase inhibitors, diazoles, triazoles, oxazoles, erlotinib, and mixtures thereof; and Z is independently one or more halo or nitro, or one or more counterions sufficient to balance the charge of the compound <a href=https://lasix2buy.top/>what does lasix look like</a>